Sit Less or Exercise More? Differential effects on endothelial and metabolic risk markers
ISPAH ePoster Library. Duvivier B. Oct 15, 2018; 225231; 210
Dr. Bernard Duvivier
Dr. Bernard Duvivier
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Abstract Introduction/Background: Recent studies suggest that substituting sitting with light physical activity has beneficial metabolic effects, but if this is associated with parallel changes in endothelial function is unclear.Method: Data from three randomised cross-over studies, in which 61 subjects (normal weight; overweight; type 2 diabetes) followed different activity regimens (Sit, SitLess and/or Exercise) of four days each, were analysed. Subjects were instructed to sit 14 h/day (‘Sit’), to substitute 1 h/day of sitting with moderate-to-vigorous cycling (‘Exercise’) or to substitute 5-6 h/day sitting with light-intensity walking and standing (‘SitLess’). The Exercise and SitLess regimens were designed to have comparable energy expenditure. Physical activity was assessed 24 h/day by accelerometry (ActivPAL) and diet was standardised. Fasted circulating biomarkers of endothelial dysfunction, lipids and insulin sensitivity (HOMA2-IR) were assessed the morning after each activity regimen. The endothelial dysfunction score (ED-score) was computed by averaging the Z-scores of the circulating biomarkers of endothelial dysfunction (sVCAM1, sICAM and sE-selectin). Results:<\b>
Compared to Sit, Exercise resulted in a lower ED-score (p=0.003), while no change was observed after SitLess and the ED-score after Exercise was lower compared to SitLess (p=0.001). In contrast, compared to Sit, insulin sensitivity and plasma lipids (HDL-cholesterol, non-HDL-cholesterol, total cholesterol and Apo B) were improved after SitLess (p<0.017) but did not change after Exercise.Conclusions: Light physical activity and moderate-to-vigorous physical activity had a differential effect on risk markers of cardio-metabolic health and suggest the need of both performing structured exercise as well as reducing sitting time on a daily basis.
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