Light physical activity and quality of life after colorectal cancer: A longitudinal analysis.
ISPAH ePoster Library. H. van E. Oct 16, 2018; 225278; 119
Eline H. van
Eline H. van
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Abstract Introduction:<\b>
Emerging evidence suggests that light-intensity physical activity (LPA) may be beneficial for the quality of life of colorectal cancer survivors. We performed a longitudinal analysis to investigate associations of LPA with quality of life, between 6 weeks until 2 years after colorectal cancer treatment. Methods:<\b>
Colorectal cancer patients (n=325) were included at diagnosis at three hospitals in the South-Eastern region of the Netherlands, with measurements at 6 weeks (n =267), 6 months (n =215), 1 year (n =169), and 2 years post-treatment (n =72). Time spent on LPA (hours/week) and relevant quality of life outcomes were measured by validated questionnaires. Linear mixed regression was performed to analyze overall longitudinal associations, as well as independent inter-individual (between participant differences) and intra-individual (within participant changes over time) associations of LPA with quality of life. Results:<\b>
In confounder-adjusted analyses, more time spent in LPA was overall significantly (P<0.05) associated with better global quality of life and physical, role and social functioning, and with less fatigue. Significant intra-individual associations over time were observed of LPA with all these outcomes, and significant inter-individual associations with physical functioning and fatigue. Conclusion:<\b>
We found that a higher level of LPA during the first two years after colorectal cancer treatment was associated with better quality of life outcomes. Further research is necessary to unravel the underlying biological mechanisms and to establish LPA as a potential target for lifestyle interventions. External funding details Wereld Kanker Onderzoek Fonds (WKOF), part of the World Cancer Research Fund International grant programme (grant number 2016/1620).
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