Daily walking time and traditional and novel inflammatory biomarkers in the elderly: A subcohort from NISSIN Project
ISPAH ePoster Library. Zhao W. 10/16/18; 225335; 110
Wenjing Zhao
Wenjing Zhao
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Abstract Introduction There is growing evidence that shows the association between physical activity and inflammatory biomarkers. But it is not yet clear whether daily walking is associated with the traditional and novel inflammatory biomarkers in the elderly.Method A subcohort of 715 Japanese community-dwelling residents aged 64/65 years was abstracted from an age-specific prospective cohort study, NISSIN Project (The sampling fraction, about 25%). Daily walking time was evaluated by self-reported questionnaires at baseline and inflammatory biomarkers were measured at baseline and after about 5-year follow-up. Generalized linear model was applied to analyze the cross-sectional and longitudinal association between daily walking time and each protein. The crude and multivariate adjusted model were conducted.ResultsWalking >= 0.5 hour/d was inversely and significantly associated with plasma Angiopoietin-like protein 2 level, and this cross-sectional association did not substantially change after adjustment for gender, work status, tobacco use, alcohol assumption, sleep duration, medical status of hypertension, hyperlipidemia and diabetes mellitus, history of heart disease, cerebrovascular disease and cancer, BMI, dietary behavior and hs-CRP. Walking >= 2 hours/d was positively and significantly associated with plasma adiponectin level before and after full adjustment. But the longitudinal association of daily walking with ANGPTL2 or adiponectin level was not detected. No any significant association between daily walking and hs-CRP was found. Conclusion We found the cross-sectional association of daily walking with the novel pro-inflammatory biomarker of ANGPTL2 and the anti-inflammatory biomarker of adiponectin. It provides new evidence of mechanisms between physical activity and health in the elderly.
Abstract Introduction There is growing evidence that shows the association between physical activity and inflammatory biomarkers. But it is not yet clear whether daily walking is associated with the traditional and novel inflammatory biomarkers in the elderly.Method A subcohort of 715 Japanese community-dwelling residents aged 64/65 years was abstracted from an age-specific prospective cohort study, NISSIN Project (The sampling fraction, about 25%). Daily walking time was evaluated by self-reported questionnaires at baseline and inflammatory biomarkers were measured at baseline and after about 5-year follow-up. Generalized linear model was applied to analyze the cross-sectional and longitudinal association between daily walking time and each protein. The crude and multivariate adjusted model were conducted.ResultsWalking >= 0.5 hour/d was inversely and significantly associated with plasma Angiopoietin-like protein 2 level, and this cross-sectional association did not substantially change after adjustment for gender, work status, tobacco use, alcohol assumption, sleep duration, medical status of hypertension, hyperlipidemia and diabetes mellitus, history of heart disease, cerebrovascular disease and cancer, BMI, dietary behavior and hs-CRP. Walking >= 2 hours/d was positively and significantly associated with plasma adiponectin level before and after full adjustment. But the longitudinal association of daily walking with ANGPTL2 or adiponectin level was not detected. No any significant association between daily walking and hs-CRP was found. Conclusion We found the cross-sectional association of daily walking with the novel pro-inflammatory biomarker of ANGPTL2 and the anti-inflammatory biomarker of adiponectin. It provides new evidence of mechanisms between physical activity and health in the elderly.
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