Lipoprotein subclasses and their associations with physical activity and sedentary time in Norwegian schoolchildren: The Active Smarter Kids study
ISPAH ePoster Library. Remy Jones P. Oct 16, 2018; 225471; 120
Paul Remy Jones
Paul Remy Jones
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Abstract Background:<\b>
Physical activity (PA) is associated with certain lipoproteins, but not consistently across lipoprotein subclasses. We examined cross-sectional associations in children between objectively measured PA and sedentary time (SED) with a number of biomarkers of lipoprotein metabolism. Methods:<\b>
We included 1055 healthy fifth-grade (mean age 10.2 yrs) Norwegian schoolchildren (47.4% females). PA intensity (light (LPA); moderate (MPA); vigorous (VPA)), and SED were assessed using accelerometry. We quantified 31 measurements of lipoprotein metabolism using nuclear magnetic resonance spectroscopy. We used linear regression (median regression for skewed data) models adjusted for age, sex, sexual maturity and socioeconomic status. Additional models were adjusted for adiposity. An isotemporal substitution regression model quantified associations of replacing 30 minutes LPA or SED with 30 minutes MVPA. We applied a false discovery rate adjustment to p-values. Results:<\b>
Total PA, LPA, MPA, VPA and SED were associated with 10, 0, 16, 19 and 5 of the 31 biomarkers, respectively. The number of significant associations were attenuated after adjusting for adiposity (10, 0, 12, 11, and 0), respectively. Substituting 30 minutes of SED or LPA for MVPA revealed significant associations with 22 and 21 biomarkers, respectively. Following adjustment for adiposity, 10 and 12 associations, respectively, remained statistically significant (p<0.05). Conclusion:<\b>
PA of higher intensity is associated with certain biomarkers of lipoprotein metabolism independent of adiposity. Substituting SED or LPA for MVPA shows favourable associations with these biomarkers. This suggests that increasing PA of at least moderate intensity may favourably affect lipoprotein metabolism in healthy children. External funding details Research Council of Norway
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