Risk of lung cancer and physical activity by smoking status and body mass index, the Norwegian Women and Cancer Study
ISPAH ePoster Library. Benjaminsen Borch K. Oct 16, 2018; 225498
Assoc. Prof. Kristin Benjaminsen Borch
Assoc. Prof. Kristin Benjaminsen Borch
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Abstract
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Abstract Introduction:<\b>
We aimed to investigate physical activity (PA) and risk of different histological subtypes of lung cancer according to smoking status and BMI and to take advantage of repeated measurements in a large cohort of women in Norway. Methods:<\b>
The study sample for the baseline data analysis consisted of 80,802 women. Repeated measurements of PA level, smoking, weight, and height were available for 54,691 women (63.2%), who were included in repeated measurement analyses combined with multiple imputation to address attrition. Cox proportional hazard regression models were used to calculate hazard ratios with 95% confidence intervals. Results:<\b>
During a median follow-up of 12.9 years, 782 cases of primary lung cancer were identified. We found an inverse dose-response association between PA and lung cancer overall. The results were consistent when using baseline data and repeated measurements of PA and possible confounders. We observed a similar trend for adenocarcinoma, but not for squamous cell or small cell carcinomas. Conclusion:<\b>
Our findings suggest a more pronounced association between lung cancer and PA levels in current and former smokers and in normal-weight and overweight participants with increasing PA levels. External funding details This project received financial support from the Norwegian Extra Foundation for Health and Rehabilitation through EXTRA funds, grant number 2012/2/0048 - 1220048001.
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