A multicomponent exercise trial for advanced prostate cancer: A study protocol
ISPAH ePoster Library. Brown M. Oct 15, 2018; 225521; 377
Dr. Malcolm Brown
Dr. Malcolm Brown
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Abstract
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Abstract Background:<\b>
Prostate cancer (PCa) is the most common cancer in men with approximately 1,100 diagnosed annually in Northern Ireland, of which 16% are advanced cases. Advanced PCa presents a considerable disease burden but promising evidence is emerging that exercise may improve several disease and treatment-related outcomes, however empirical evidence remains limited. This trial will examine a moderate intensity, home-based exercise program in men with advanced PCa. Methods:<\b>
30 men diagnosed with advanced PCa will be recruited. Eligible patients will be screened and undergo medical evaluation. All men will receive a 12-week multicomponent, self-managed, home-based exercise intervention with 24-week follow-up. This progressive exercise program will consist of moderate intensity (55-70% maximum heart rate) walking and strengthening exercises. At baseline, 12 and 24 weeks outcome measures will be determined (height, weight, hip and waist circumference, physical fitness and quality of life) as will 7 day accelerometer assessment. Behavioural change consultation and continued support will be provided. The primary endpoint relates to the feasibility, accessibility and acceptability of the intervention (via semi-structured interviewing of participants, non-participants and co-investigators). Secondary endpoints will examine skeletal-related events, pain, fatigue, physical function and quality of life. Quantitative data will be analysed for mean changes from baseline using paired sample t-tests. Results:<\b>
The results will provide an indication of the intervention feasibility and data to inform a future, larger, phase III randomised control trial. Conclusion:<\b>
We propose this study will measurably impact quality of life in men with advanced PCa. External funding details HSC Public Health Agency Research and Development Division.
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